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KMID : 0352519820190030631
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Korea Univercity Medical Journal
1982 Volume.19 No. 3 p.631 ~ p.341
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Histochemical observation of interaction between chlorambucil and ginseng saponin on RNA, DNA and PAS positive materials in hepatocytes of weanling rat
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Abstract
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The effects of interaction between chlorambucil and crude ginseng extract (ginseng saponin) had been investigated on liver cell of 90 experimental weanling albino rats from 22 healthy primiparous mother rats by means of histochemical detection as RNA, DNA and PAS positive materials.
1. Severe regressive changes of the liver tissue, especially on the portal area, induced by intraperitoneal administration of single dose of chlorambucil rated 0.2mg/0.lcc per 20gm of body weight had been protected or recovered from the degeneration by following administration of single dose of the crude ginseng extract rated 1.Omg/0.1cc per 20gm of the body weight of young.
2. An abrupt declination of PAS positive material in hepatocyte due to use of chlorambucil was contrasted with a gradual inclination of it induced by use of crude ginseng extract, and the effect of the latter appears to be contributed for recovering the lower PAS reaction into that of the normal on the former hepatic cellular change.
3. A declination of stain property on RNA to Azure B was resulted from the use of chlorambucil, while that of DNA was not affected until 24 hours and later it was increased by 36 hours after the administration.
4. A slight decrease of the staining in both the DNA and RNA was recovered the property by 48 hours after the administration of crude ginseng extract.
5. On concomitant administration of both the chlorambucil and crude ginseng extract the staining property of the RNA to Azure B was shown a decrease in the initial stage, and was recovered in that of the normal immediately thereafter without influencing that for DNA.
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